YOUR SKIN DESERVES

Prescription-Strength Skincare

Alloy's M4 skincare is the first estriol-powered formula clinically proven to rebuild collagen, restore elasticity, and visibly reduce wrinkles in as little as 8 weeks.

Starting at $30 per month

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Clinically Proven M4 Skincare

Alloy became the first company to offer skincare with estriol—and independent tests showed significant, measurable results. In as little as 8 weeks, women using M4 creams saw visibly firmer, smoother, more radiant skin.

4.6

stars from 2k Trustpilot skin reviews

95%

felt smoother skin with M4 Body Treatment

88%

improved elasticity with M4 Face Cream

20%

more supple skin with M4 Eye Cream

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Featured in Oprah's O-wards

Menopause-Expert Doctors

Simple Intake Form

HSA and FSA Eligible

Transform Your Skin

Target fine lines, wrinkles, and signs of aging with prescription power

BEST SELLER

M4 Face Cream Rx

Estriol

$150.00

Restore elasticity, hydrate deeply and build collagen—this powerful estriol-enriched face cream does it all

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NEW

M4 Body Treatment Rx

Estriol + Peptides

$195.00

The only prescription estriol + peptide body treatment proven to smooth, firm, and restore skin on hands, arms, chest, and knees

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M4 Eye Cream Rx

Estriol + Peptides

$90.00

Target fine lines and boost collagen with a lifting and renewing cream that smooths and firms delicate skin

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Oprah's O-wards

M4 Face Serum Rx

Estriol + Peptides + Hyaluronic Acid

$159.00

Smooth, firm and repair your skin with this deeply hydrating serum packed with collagen-boosting estriol

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Tretinoin Face Cream Rx

Tretinoin + Niacinamide

$90.00

Topical treatment compounded with niacinamide and aloe for acne, fine lines, hyperpigmentation, and discoloration

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Rosacea Face Cream Rx

Azelaic Acid + Metronidazole + Ivermectin

$99.00

Triple-action prescription rosacea cream clinically designed to target redness, inflammation, and sensitivity

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ESTRIOL: A TRUE GAME CHANGER

Estriol, a form of estrogen and the powerhouse ingredient in our M4 products, builds collagen, increases elasticity, and restores moisture.

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Targeted Treatments, Smart Savings

Get radiant, resilient skin with exclusive sets designed for visible results

$100 OFF

Head to Toe Set

M4 Face Cream Rx, M4 Eye Cream Rx & M4 Body Treatment Rx

$335.00 $435.00

Three estriol-based formulas work together to address signs of aging on your whole body.

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$100 OFF

Glow & Go Set

M4 Face Cream Rx, M4 Face Serum Rx, & M4 Eye Cream Rx

$299.00 $399.00

The complete M4 set for hormone-deprived skin on your face, for AM or PM routines.

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$30 OFF

Daily Strength Duo

M4 Face Cream Rx & M4 Eye Cream Rx

$210.00 $240

This estriol-based set is clinically proven to boost collagen production, deeply hydrate, and increase elasticity

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$30 OFF

Power Pair

M4 Face Cream Rx & Tretinoin Face Cream Rx

$210.00 $240.00

A powerhouse duo that delivers surface renewal and deep repair for younger-looking, smoother skin

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The Reviews Are In, and They're Glowing

I have been using Alloy M4 and it’s unbelievable. Literally a miracle for my skin.

- Deborah C.

Obsessed with Alloy's M4 cream. My skin is ✨GLOWING✨

- Harprett T

This has been a game changer for my 52 year old skin. Wow!

- Laura T.

I have been using the M4 for 4 months now. I’m glowing! My face looks smoother and hydrated...So happy I found this magic in a bottle.

- Stacy M.

Precision Skincare in Every Step

Step 1

Treat the Eye Area

On clean skin, apply 1 pump of M4 Eye Cream Rx to each under eye and lid area

Step 2

Select Your M4 Base Treatment

AM routine or lighter hydration: Apply 2 pumps of M4 Face Serum Rx

PM routine or deeper hydration: Apply 2 pumps of M4 Face Cream Rx

Step 3

Lock in & Protect

AM: Follow with a moisturizer, SPF, and makeup as needed

PM: Apply a moisturizer or retinoid, like Alloy's Tretinoin Face Cream Rx

As directed by your provider

Step 4

Treat the Body

Apply 1 pump of M4 Body Treatment Rx to hands, arms, chest, legs above the knees, and stomach

More to Know on Skincare

Learn more about caring for your skin from the science behind key ingredients to building a routine that works for you.

Collagen & Estrogen: Everything Women Need To Know

Common Perimenopause Skin Problems & How To Fix Them

Everything You Need to Know About Estriol Cream

Tretinoin cream: What is it and how to use it? A Beginner's Guide

Skin that feels like yours again

Your skin isn't aging, it's changing. Estriol gives it exactly what it's been missing.

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Frequently asked questions

Are the M4 products right for me?+

Can I use this with hormone therapy?+

What were the results of the clinical studies of M4 products?+

When should I start using the M4 Skincare line?+

Do I need progesterone?+

Is M4 Rx eligible for HSA or FSA reimbursement?+

Where is Alloy available?+